伊莉莎白國王菌屬（Elizabethkingia spp.） 為新興的伺機性革蘭氏陰性菌，屬於非發酵、具氧化酶活性的桿狀細菌。此菌常存在於潮濕環境及醫療照護設施中，包括供水系統、加濕器及醫療器材等。Elizabethkingia spp. 多與院內感染相關，可引起菌血症、肺炎及腦膜炎等疾病，尤其好發於免疫功能低下或重症病人。由於其具有先天性多重抗藥性，臨床治療選擇有限，感染後死亡率較高，因此已成為全球抗藥性監測與感染管制的重要關注菌種之一。
TSAR 研究成果：
1. Huang T-W, Yeh T-K, Hsu S-Y, Tan M-C, Huang W-C, Kuo S-C. In vitro and in vivo efficacy of vancomycin against Elizabethkingia species and the impact of increased vancomycin MICs. Microbiol Spectr. 2025 Nov 4;13(11):e0237125. doi: 10.1128/spectrum.02371-25. Epub 2025 Oct 1. PMID: 41031831; PMCID: PMC12584665.
2. Chen PJ, Tan MC, Huang WC, Hsu SY, Chen TL, Yang CY, Kuo SC. The individual contributions of blaB, blaGOB and blaCME on MICs of β-lactams in Elizabethkingia anophelis. J Antimicrob Chemother. 2024 Jul 1;79(7):1577-1580. doi: 10.1093/jac/dkae137. PMID: 38742706; PMCID: PMC11215548.
3. Tan MC, Huang YC, Chen PJ, Huang WC, Hsu SY, Wang HY, Liou CH, Sun JR, Lauderdale TY, Kuo SC. In vitro and in vivo evidence discourages routine testing and reporting of piperacillin/tazobactam susceptibility of Elizabethkingia species. J Antimicrob Chemother. 2024 Jan 3;79(1):200-202. doi: 10.1093/jac/dkad322. PMID: 37850648; PMCID: PMC10761272.
4. Yang YS, Huang TW, Huang YC, Huang WC, Hsu SY, Wu HC, Chen FJ, Shang HS, Sytwu HK, Kuo SC. In vitro and in vivo efficacy of minocycline-based therapy for Elizabethkingia anophelis and the impact of reduced minocycline susceptibility. Int J Antimicrob Agents. 2022 Nov-Dec;60(5-6):106678. doi: 10.1016/j.ijantimicag.2022.106678. Epub 2022 Sep 29. PMID: 36184015.
5. Lee YL, Liu KM, Chang HL, Liao YC, Lin JS, Kung FY, Ho CM, Lin KH, Chen YT. The Evolutionary Trend and Genomic Features of an Emerging Lineage of Elizabethkingia anophelis Strains in Taiwan. Microbiol Spectr. 2022 Feb 23;10(1):e0168221. doi: 10.1128/spectrum.01682-21. Epub 2022 Jan 19. PMID: 35044198; PMCID: PMC8768576.
6. Kuo SC, Tan MC, Huang WC, Wu HC, Chen FJ, Liao YC, Wang HY, Shiau YR, Lauderdale TL. Susceptibility of Elizabethkingia spp. to commonly tested and novel antibiotics and concordance between broth microdilution and automated testing methods. J Antimicrob Chemother. 2021 Feb 11;76(3):653-658. doi: 10.1093/jac/dkaa499. PMID: 33258923; PMCID: PMC8600004.