克雷伯氏肺炎桿菌為格蘭氏陰性菌，大腸桿菌屬，兼性厭氧，可引起肺炎、敗血症、腦膜炎、肝膿瘍、泌尿系統感染及腎膿瘍等感染症，其多醣形成的莢膜為其特點，並為致病機轉之一。院內感染之多重抗藥克雷伯氏肺炎桿菌與社區型基因型不同，易有ESBL，近年carbapenem抗藥之克雷伯氏肺炎桿菌盛行率也漸漸在上升。
TSAR 研究成果：
1. Lee YL, Liu CE, Wang WY, Tan MC, Chen PJ, Shiau YR, Wang HY, Lai JF, Huang IW, Yang YS, Kuo SC. Antimicrobial resistance among imipenem-non-susceptible Escherichia coli and Klebsiella pneumoniae isolates, with an emphasis on novel β-lactam/β-lactamase inhibitor combinations and tetracycline derivatives: The Taiwan surveillance of antimicrobial resistance program, 2020-2022. J Microbiol Immunol Infect. 2025 Apr;58(2):219-225. doi: 10.1016/j.jmii.2025.01.006. Epub 2025 Feb 6. PMID: 39934015.
2. Tsai CC, Lin JC, Chen PC, Liu EY, Tsai YK, Yu CP, Li JJ, Wang CH, Fung CP, Lin FM, Chang FY, Siu LK. A 20-Year Study of Capsular Polysaccharide Seroepidemiology, Susceptibility Profiles, and Virulence Determinants of Klebsiella pneumoniae from Bacteremia Patients in Taiwan. Microbiol Spectr. 2023 Jun 15;11(3):e0035923. doi: 10.1128/spectrum.00359-23. Epub 2023 May 16. PMID: 37191538; PMCID: PMC10269490.
3. Lin WP, Wang JT, Chang SC, Chang FY, Fung CP, Chuang YC, Chen YS, Shiau YR, Tan MC, Wang HY, Lai JF, Huang IW, Lauderdale TL. The Antimicrobial Susceptibility of Klebsiella pneumoniae from Community Settings in Taiwan, a Trend Analysis. Sci Rep. 2016 Nov 8;6:36280. doi: 10.1038/srep36280. PMID: 27824151; PMCID: PMC5099973.