K. pneumoniae is gram-negative, facultatively anaerobic, bacilli. It is a member of Enterobacteriaceae. It most commonly causes pneumonia, bloodstream infections, meningitis, liver abscess, urinary tract infections or kidney abscess. The polysaccharide capsule is the notorious virulence factors. The virulent strains in the community are different from those causing healthcare-associated infections. In hospitals, K. pneumoniae obtained ESBL and become multidrug resistant. Recently, emergence of carbapenem-resistant K. pneumoniae poses great threat to healthcare system.
TSAR Publications：
1. Lee YL, Liu CE, Wang WY, Tan MC, Chen PJ, Shiau YR, Wang HY, Lai JF, Huang IW, Yang YS, Kuo SC. Antimicrobial resistance among imipenem-non-susceptible Escherichia coli and Klebsiella pneumoniae isolates, with an emphasis on novel β-lactam/β-lactamase inhibitor combinations and tetracycline derivatives: The Taiwan surveillance of antimicrobial resistance program, 2020-2022. J Microbiol Immunol Infect. 2025 Apr;58(2):219-225. doi: 10.1016/j.jmii.2025.01.006. Epub 2025 Feb 6. PMID: 39934015.
2. Tsai CC, Lin JC, Chen PC, Liu EY, Tsai YK, Yu CP, Li JJ, Wang CH, Fung CP, Lin FM, Chang FY, Siu LK. A 20-Year Study of Capsular Polysaccharide Seroepidemiology, Susceptibility Profiles, and Virulence Determinants of Klebsiella pneumoniae from Bacteremia Patients in Taiwan. Microbiol Spectr. 2023 Jun 15;11(3):e0035923. doi: 10.1128/spectrum.00359-23. Epub 2023 May 16. PMID: 37191538; PMCID: PMC10269490.
3. Lin WP, Wang JT, Chang SC, Chang FY, Fung CP, Chuang YC, Chen YS, Shiau YR, Tan MC, Wang HY, Lai JF, Huang IW, Lauderdale TL. The Antimicrobial Susceptibility of Klebsiella pneumoniae from Community Settings in Taiwan, a Trend Analysis. Sci Rep. 2016 Nov 8;6:36280. doi: 10.1038/srep36280. PMID: 27824151; PMCID: PMC5099973.