Group B Streptococcus (GBS) is a major cause of infections in newborns and has become an increasing concern among adults, particularly the elderly and those with chronic illnesses. While it is widely recognized in pediatric care, its role in adult invasive infections is gaining attention.
Through a national surveillance program, we collected GBS samples from patients of all ages to study differences in strain types, antibiotic resistance, and disease severity. Our findings show that the types of GBS causing infections vary by age group. In infants under one year, serotype III predominated, whereas serotype VI became more dominant in adults over 55 years, highlighting an age-dependent shift in serotype distribution. Certain strains also show signs of antibiotic resistance, which may complicate future treatment.
We are currently collaborating with the Wellcome Sanger Institute in the UK to perform whole-genome sequencing on these strains (Juno2 Global GBS Project). This work allows us to better understand the genetic evolution of GBS in Taiwan and compare it with global trends. The results will help guide future vaccine development and public health strategies.