大腸桿菌為格蘭氏陰性菌，大腸桿菌屬，兼性厭氧，是腸內常在菌之一，偶而造成人類感染，較常見的感染為泌尿道，腹瀉，或腹腔內感染，也可能造成肺炎或小孩之腦膜炎。某些毒性較強之菌株，甚至會造成健康人群聚感染，留下嚴重後遺症，甚至死亡。院內感染大腸桿菌也扮演重要角色，且帶有ESBL造成多重抗藥，近年有一小部分形成carbapenem抗藥之大腸桿菌，造成治療困難。
TSAR 研究成果：
1. Lee YL, Liu CE, Wang WY, Tan MC, Chen PJ, Shiau YR, Wang HY, Lai JF, Huang IW, Yang YS, Kuo SC. Antimicrobial resistance among imipenem-non-susceptible Escherichia coli and Klebsiella pneumoniae isolates, with an emphasis on novel β-lactam/β-lactamase inhibitor combinations and tetracycline derivatives: The Taiwan surveillance of antimicrobial resistance program, 2020-2022. J Microbiol Immunol Infect. 2025 Apr;58(2):219-225. doi: 10.1016/j.jmii.2025.01.006. Epub 2025 Feb 6. PMID: 39934015.
2. Lin JC, Kristopher Siu LK, Chang FY, Wang CH. Mutations in the pmrB gene constitute the major mechanism underlying chromosomally encoded colistin resistance in clinical Escherichia coli. J Glob Antimicrob Resist. 2024 Sep;38:275-280. doi: 10.1016/j.jgar.2024.06.013. Epub 2024 Jul 10. PMID: 38996871.
3. Wang JT, Chang SC, Chang FY, Fung CP, Chuang YC, Chen YS, Shiau YR, Tan MC, Wang HY, Lai JF, Huang IW, Yang Lauderdale TL. Antimicrobial Non-Susceptibility of Escherichia coli from Outpatients and Patients Visiting Emergency Rooms in Taiwan. PLoS One. 2015 Dec 3;10(12):e0144103. doi: 10.1371/journal.pone.0144103. PMID: 26632819; PMCID: PMC4669119.